Hydroxyl Radical as Key Intermediate in Curing Action of Artemisinin and its Analogs
نویسندگان
چکیده
منابع مشابه
An important role of intramolecular free radical reactions in antimalarial activity of artemisinin and its analogs.
The kinetic schemes of intramolecular reactions of five analogs of artemisinin were built. The method of intersecting parabolas was used for the calculation of activation energies and rate constants of each elementary step of these schemes. The competition between monomolecular and bimolecular free radicals was taken into account. It was evidenced that the intramolecular oxidation of these comp...
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We have developed a simple ESR spin trapping based method for hydroxyl (OH) radical scavenging-capacity determination, using iron-free OH radical source. Instead of the widely used Fenton reaction, a short (typically 5 seconds) in situ UV-photolysis of a dilute hydrogen peroxide aqueous solution was employed to generate reproducible amounts of OH radicals. ESR spin trapping was applied to quant...
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ژورنال
عنوان ژورنال: Medicinal Chemistry
سال: 2014
ISSN: 2161-0444
DOI: 10.4172/2161-0444.1000233